A. Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of year to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North Americal aboriginal has used Alfalfa seed as food, such as making bread and mush.
B. Nutritional Supplements
1. Essential amino acids
2. Calcium
3. Magnesium
4. Potassium
5. Iron
6. Phosphorus
7. Zinc
8. Beta carotene
9. vitamin C
10. vitamins D
11.Vitamin E
12. Vitamin K
13. Etc.
C. Health benefits of Alfalfa
1. Antioxidant
In a study of measurements of pH, water holding capacity, color, oxymyoglobin content, TBARS and oxidation-reduction potential in evaluating the effects of a dietary protein-xanthophylls (PX) concentrate of alfalfa to turkey diets conducted by University of Life Sciences in Lublin, Skromna 8, 20-704 Lublin, Poland.(1), researchers found that TBARS and oxidation-reduction potential values suggested that the inclusion of the concentrate to turkey diets acts as an antioxidant in the raw meat.
2. Cholesterol
In a study to test the effect of Alfalfa used in traditional medicine to treat high blood cholesterol conducted by Malinow MR, McLaughlin P, Stafford C.(2), in 3 human volunteers during ingestion of diets containing alfalfa seeds (AS) for 3 weeks, researchers found that Plasma cholesterol concentrations were reduced and No signs of toxicity were detected through serum determinations of multiple parameters. The ingestion of AS in rats decreased the concentration of plasma cholesterol, reduced intestinal absorption of exogenous and endogenous cholesterol, and increased fecal biliary excretion.
3. Hyperlipoproteinemia
In a study of Fifteen patients with hyperlipoproteinemia (HLP), types IIA (n = 8), IIB (n = 3) and IV (n = 4) were given 40 g of heat prepared alfalfa seeds 3 times daily at mealtimes for 8 weeks with otherwise unchanged diet, conducted by Mölgaard J, von Schenck H, Olsson AG.(3), found that patients with type II HLP alfalfa treatment caused after 8 weeks a maximal lowering of pretreatment median values of total plasma cholesterol from 9.58 to 8.00 mmol/l (P less than 0.001) and low density lipoprotein (LDL) cholesterol from 7.69 to 6.33 mmol/l (P less than 0.01), which corresponds to decreases of 17% and 18%, respectively. Maximal decrease was 26% in total cholesterol and 30% in LDL cholesterol. In two patients with hypercholesterolemia the LDL cholesterol decreased less than 5%. Apolipoprotein B decreased in the same period from 2.17 to 1.43 g/l (P less than 0.05) in type II HLP, corresponding to 34% decrease, whereas apolipoprotein A-I did not change. Body weight increased slightly during the first 4 weeks of alfalfa treatment (P less than 0.001) probably because of the caloric content in the alfalfa seeds. After cessation of treatment, all lipoprotein concentrations returned to pretreatment levels. We conclude that alfalfa seeds can be added to the diet to help normalize serum cholesterol concentrations in patients with type II HLP.
4. Disease of autoimmune
In a study of five groups of 12-week-old female mice were per oral treated with vehicle (control), lyophilized AS (550 mg wt/kg BW), ASEA (ASEA, 25 mg/kg BW), coumestrol (CUM, 0.075 mg/kg BW) and tamoxifen (TAM, 0.375 mg/kg BW) as the positive control, conducted by Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan (4), researchers found that alhalfa decreased the disease severity, increased survival and life span of the autoimmune-prone MRL-lpr/lpr mice, suggesting a potential of ASEA in the treatment of autoimmune diseases.
5. Anti-inflammatory activity
In a study of anti-inflammatory effects may be used for inflammatory disorders by examining alfalfa sprout ethyl acetate extract (ASEA) in ,ice coducted by College of Life Science, National Taiwan University, Taipei, Taiwan, Republic of China.(5), researchers found that significantly higher survival rates than the control group and suggests that ASEA supplementation can suppress the production of pro-inflammatory cytokines and alleviate acute inflammatory hazards.
6. Systemic lupus erythematosus
In experimental studies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented,conducted by Oregon Health Sciences University, Portland (6), researchers indicate that a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.
7. Menopause symptoms
In a study of Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity, conducted by University of Illinois at Chicago (7), researchers found thatestrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.
8. Neuroprotective activity
In a study of the neuroprotective effect of methanol extract of Medicago sativa (MS, Alfalfa) on ischemia and reperfusion-induced cerebral injury in mice, conducted by Institute of Pharmacy, Solan 173 223, India. (8)found that suggest that treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity.
9. Etc
D. Side effects
1. High amount of vitamin K may reduce the effectiveness of anticogulation medicine
2. Causing additive effects for women who are under estrogen replecement therapy or taking the oral contraceptive pill.
3. It may cause stomach upset and diarrhea
4. Etc.
Healthy Happy Herbs
A Beginner's Guide To Herbs And
Herb Gardening, Step by step,
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(1) "Effect of protein-xanthophylls (PX) concentrate of alfalfa supplementation on physico-chemical properties of turkey breast and thigh muscles during ageing" by Karwowska M, Stadnik J, Dolatowski ZJ, Grela ER., posted in PubMed
(2) "Alfalfa seeds: effects on cholesterol metabolism." Posted in PubMed
(3) "Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia", posted in PubMed
(4) " The ethyl acetate extract of alfalfa sprout ameliorates disease severity of autoimmune-prone MRL-lpr/lpr mice" by Hong YH, Huang CJ, Wang SC, Lin BF., posted in PubMed
(5) "Ethyl acetate extracts of alfalfa (Medicago sativa L.) sprouts inhibit lipopolysaccharide-induced inflammation in vitro and in vivo" by Hong YH, Chao WW, Chen ML, Lin BF., posted in PubMed
(6) "Dietary amino acid-induced systemic lupus erythematosus" by Montanaro A, Bardana EJ Jr., posted in PubMed
(7) "Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms" byLiu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL., posted in PubMed
(8) "Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult" by Bora KS, Sharma A., posted in PubMed
Tuesday, September 20, 2011
Monday, September 19, 2011
Allergies: Grass Pollen Allergy
Allergy is the over reaction of immune system to harmless substances after entering our body affecting 1 in every 3 people.
Cure Allergies Completely Naturally
Allergy Free For Life All Natural Cure
For Stopping Your Allergies In 5 Days
Causes
Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
over production of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against harmless substance that lead to mediated release of histamine and other mediators from mast cells and basophils, resulting in allergic reaction, including mucus secretion, sneezing, itching, etc.
F. Grass pollen allergy
Grass Pollen Allergy is one of most common allergy happened seasonally when the grasses are pollinated and carried by wind, including Bermuda grass, Johnson grass, Kentucky bluegrass, Orchard grass, Sweet vernal grass,etc.. Unlike other allergies can occur year round, such as pet dander and house dust mite.
F. 1. How to determine the severity of the allergic effects
Depending to the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
F.1.1. The severity scale from +1 to +4
+1. The first level of stimulation
If there is no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient have become irritable, hyperactive, tense, thirsty, etc. after a suspected allergic foods is eaten
+3. The third level of stimulation
The patient have become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient have become mania, agitation, over excitement, etc.
F.1.2. Degeneration scale from -1 to -4
-1. If a patient is experience symptoms of reaction of runny nose, hive, diarrhea, etc.
-2. If a patient is experience symptoms of reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experience symptoms of reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experience symptoms of reaction of sever depression, paranoia, etc.
F.2. Symptoms
Symptoms are the result in nasal congestion, due to Grass Pollen cause of a chain reaction that leads the mast cells in these tissues to release histamine, causing dilation of many small blood vessels in the nose and swelling to nasal pathway of which can affects the daily activity including quality of life, productivity, and other chronic conditions, including asthma. of which can affects the daily activity including quality of life, productivity, and other chronic conditions, including asthma.
In the study of "Bronchial Allergen Challenge Using the Medicaid Dosimeter" by Schulze J, Rosewich M, Dressler M, Riemer C, Rose MA, Zielen S. (Source from Department of Allergy, Pulmonology and Cystic Fibrosis, Children's Hospital, Goethe-University, Frankfurt a.M., Germany. posted in PubMed, researchers suggested that The use of aerosol provocation system to calculate the PD(20)FEV(1) allergen is a time saving procedure and is less prone to errors because only one dilution of the allergen is used. The repeatability in well-defined subjects is excellent to study the mechanisms of allergen-induced airway inflammation and the development of new treatments for allergic diseases.
and
1. Asthma-like symptoms
2. Itching
3. Sneezing
4. Wheezing
5. Sinus pain
6. Tearing eyes
7. Runny nose
8. Itchy eyes and throat 9. Etc.
F.3. Diagnosis
If you are experience Allergic Rhinitis, it is possible to find what types of allergen have trigger that. After recording the family history and a complete physical exam. you doctor may order
1. Skin test
a. Intradermal test
It is one of most common test but time consuming( some patient may return for more 20 time for the injection) in diagnosis of allergy and depending to the symptoms, by injecting small amounts of diluted allergens into the top layers of the skin to see how the immune system react to them.
b. Skin prick testing
Similar to the Intradermal test, but the diagnosis involves in applying a drop of allergen into to punctures made on the skin.
2. Blood test ((RadioAllergoSorbent Test)
This is the test for evaluating of the levels of IgE-mediated food allergies react to a particular allergen. If you RAST score is higher than the predictive value for that food, 95% chance you will have an allergic reaction. Unfortunately, non-IgE mediated allergies cannot be detected by this method.
3. Challenge Tests
Because of the risk of anaphylaxis, most doctors will avoid the test unless it is absolutely necessary and the test is performed only in the hospital. In this test, suspected allergen package into capsule taken by patient and signs or symptoms of an allergic reaction are observed.
4. Etc.
F.4. Prevention
Grass Pollen Allergy grass pollen levels can be affected by temperature, time of day, rain, etc.. There is no way to prevent them even if you want to lock your self away from the season. But one can always enhance the immune system by eating healthy and living a healthy lifestyle. For more information of healthy foods, visit 100+ Healthy Foods Classification
F.5. Treatments
F.5.1. Conventional medicine
According to the "Treatment of allergic rhinitis." American Family Physician - Volume 81, Issue 12 (June 2010), posted in MD preview, the writer wrote that allergic rhinitis is a common chronic respiratory illness that affects quality of life, productivity, and other comorbid conditions, including asthma. Treatment should be based on the patient's age and severity of symptoms. Patients should be advised to avoid known allergens and be educated about their condition. Intranasal corticosteroids are the most effective treatment and should be first-line therapy for mild to moderate disease. Moderate to severe disease not responsive to intranasal corticosteroids should be treated with second-line therapies, including antihistamines, decongestants, cromolyn, leukotriene receptor antagonists, and nonpharmacologic therapies (e.g., nasal irrigation). With the exception of cetirizine, second-generation antihistamines are less likely to cause sedation and impair performance. Immunotherapy should be considered in patients with a less than adequate response to usual treatments. Evidence does not support the use of mite-proof impermeable covers, air filtration systems, or delayed exposure to solid foods in infancy.
1. There is no specific treatment for Hay fever, but depending to the symptoms. Medication includes bronchodilators, anti-allergics, antihistamines, NSAIDs, etc.
2. Allergic shot
Allergy shot, also known as immunotherapy, contains extracts from the most common substance which people are allergic to, including pollen, insects, pets, etc., by providing long-term relief from certain symptoms. In some people, after series of allergic shot, the disease is cured.
F.5.2. Nutritional supplements
1. Antioxidants
Since Allergies are caused by immune over reaction of certain harmless substance, enhancing immue system is one of the best way to prevent and treat them as some researchers suggested that allergies may be caused by weakened immune system over aggression. Vitamin A, E, C are antioxidants and free radical scavengers, they protect the immune system from free radicals attack and help to reduce levels of histamine in the blood. For more information of antioxidants and health effects
2. Vitamin D
According to the article " Vitamin D deficiency may be a factor in development of allergies posted in Washing Post, Monday, March, 7, 2011, " Allergies and Vitamin D, Youths low in 'sunshine vitamin' may be more prone to allergies",the author wrote that analyzed data on 6,590 people, roughly half of them 21 years of age and younger and half older. The group was deemed representative of the U.S. population. Vitamin D levels were determined by blood tests, as was sensitivity to 17 common allergens. Among the youths, food and environmental allergies were greater in those with lower levels of Vitamin D. Young people deficient in Vitamin D were about twice as likely as those with higher levels of the nutrient to have peanut or ragweed allergies and nearly five times as likely to be allergic to oak.
3. B-complex
in a study of "Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults." by Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN., USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111. posted in US National Library of Medicine National Institutes of Health, researchers found that Vitamin B-6 deficiency impairs in vitro indices of cell-mediated immunity in healthy elderly adults. This impairment is reversible by vitamin B-6 repletion.
4. Coenzyme Q10
It is an immune and nervous system enhancer, according to the article of "CoQ10 Helps the Immune System and Brain Function" by A.S. Gissen, posted in Immunesupport.com, the author wrote that In 1970, it was first reported that CoQ6 and CoQ10, when administered to rats, significantly enhanced immune cells' ability to kill bacteria, as well as elevated their antibody response.
5. Alpha lipoic acid
Alpha lipoic acid is another antioxidant which promotes the immune system by enhabcing the function of other antioxidants such as vitamin C, E, glutathione, etc. according to the article of "A relatively unknown antioxidant, alpha-lipoic acid, may be more potent than vitamins C and E" by Robert Sander, the author wrote that Because both alpha-lipoic acid and dihydrolipoic acid are antioxidants, their combined actions give them greater antioxidant potency than any natural antioxidant now known, Packer says. He notes another property of alpha-lipoic acid that makes it a great antioxidant. Since it is soluble in both water and fat, it can move into all parts of the cell to neutralize free radicals. Vitamin C, on the other hand, is limited to the watery parts of cells because it is soluble only in water; while vitamin E is soluble only in fat and sticks to the fatty parts of cells.
7. Etc.
F.5.3. Herbs
1.Panax Ginseng
In a study of "Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice." by
It is best known for treating cold and flu and enhances immune system against alll types of foreign invasion. According to the study of "Immunomodulatory Effects of Aged Garlic Extract" Eikai Kyo, Naoto Uda, Shigeo Kasuga and Yoichi Itakur, Posted in the "Journal of Nutrition" in March 2001, researchers strongly suggest that AGE (Aged Garlic Extract) could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.
3. Turmeric
Turmeric paste has been used in traditional herbal medicine as an antimicrobial and anti-inflammatory agent, it also helps to treat allergy. According to an article "Vitamin D and turmeric for allergies" by Joe Graedon and Teresa Graedon posted in Washington Post, May 11-2009, the authors wrote that In animal studies, turmeric prevents the release of histamine from mast cells (Molecular Nutrition and Food Research, September 2008). If it works similarly in humans, this would prevent allergy symptoms from developing.
4. Butterbur
Has been used over thousand of years in herbal medicine in treating symptoms of allergy, including to treat coughs,, asthma, stress, muscle relaxant, etc..According to the article of "Allergy" posted in The University of Michigan health System, the article indicated Two double-blind studies have compared butterbur extract to standard antihistamine drugs in people with hay fever. The first compared it with the drug cetirizine (Zyrtec) and found the drug and butterbur extract relieved symptoms equally well. However, cetirizine caused significantly more adverse effects, including a high rate of drowsiness.4 The second study compared butterbur extract with fexofenadine (Allegra) and placebo. Butterbur extract was as effective as fexofenadine at relieving symptoms, and both were significantly better than placebo.
5. Etc.
F.5.4. Traditional Chinese medicine
In a study of "Complementary and alternative medicine in pediatric allergic disorders." by Li XM. (Source from Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA., posted in PubMed, researcher indicated that in the last 2-3 years, there have been more controlled studies of TCM for allergic asthma and allergic rhinitis. Several publications including ours indicate that some TCM herbal formulas are well tolerated and produce some level of efficacy. Some herbal formulas also showed beneficial immunomodualtory effects. Several preclinical studies demonstrated that the food allergy herbal formula-2 was effective in protecting against peanut anaphylaxis in animal models. Two TCM products have entered clinical trials in the United States for treating asthma and food allergy, respectively. Both of these trials include children. In Summary, researcher concluded that Recent studies indicate that TCM therapy including herbal medicines and acupuncture for allergic disorders in children is well tolerated. There are also promising clinical and objective improvements. More controlled clinical studies are encouraged.
1. Xin Yi Hua is a lily-shaped flower with a hairy bud and Xin-yi-san (Magnolia Flower Powder)
a. It is a type of traditional Chinese medicine used to treat allergy and dramatically reduces the symptoms of sneezing, anosmia, nasal congestion and profuse rhinorrhea (runny nose) caused by allergies triggered by dust mites, pets and fungi.
According to the study of "Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects" by
Sien-Hung Yang, Chia-Li Yu, Ying-Lin Chen, Sheng-Lin Chiao, Mei-Ling Chen f. Posted in International Immunopharmacology 10 (2010) 951–958, researchers found that this proposal is based on the fact that different combinations of Chinese herbs involve different mechanisms. It appears that the immunosuppressive and anti-inflammatory effects derived from the mixed formula of Chinese herbs are broader than XYS. Nevertheless,we found that XYS alone sufficiently exerts immunomodulatory effects on patients with AR.
In conclusion, this study provides evidence to support that XYS, when used singly, is beneficial in nasal allergic inflammation through enhancing IL-10 and IL-8 production.
b. Ingredient
Main use: Expels wind-cold, unblocks nasal passages, congestion, loss of smell, sinus headache.
You can also view my home page for more health series and article
http://medicaladvisorjournals.blogspot.com/
or follow me on twitter
http://twitter.com/kylejnorton
Cure Allergies Completely Naturally
Allergy Free For Life All Natural Cure
For Stopping Your Allergies In 5 Days
Causes
Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result of
over production of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against harmless substance that lead to mediated release of histamine and other mediators from mast cells and basophils, resulting in allergic reaction, including mucus secretion, sneezing, itching, etc.
F. Grass pollen allergy
Grass Pollen Allergy is one of most common allergy happened seasonally when the grasses are pollinated and carried by wind, including Bermuda grass, Johnson grass, Kentucky bluegrass, Orchard grass, Sweet vernal grass,etc.. Unlike other allergies can occur year round, such as pet dander and house dust mite.
F. 1. How to determine the severity of the allergic effects
Depending to the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
F.1.1. The severity scale from +1 to +4
+1. The first level of stimulation
If there is no symptoms at all or If the patient is alert and function morally after allergic is eaten
+2. The second level of stimulation
The patient have become irritable, hyperactive, tense, thirsty, etc. after a suspected allergic foods is eaten
+3. The third level of stimulation
The patient have become hypomanic, aggressive, apprehensive, etc.
+4. The fourth level of stimulation
The patient have become mania, agitation, over excitement, etc.
F.1.2. Degeneration scale from -1 to -4
-1. If a patient is experience symptoms of reaction of runny nose, hive, diarrhea, etc.
-2. If a patient is experience symptoms of reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experience symptoms of reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experience symptoms of reaction of sever depression, paranoia, etc.
F.2. Symptoms
Symptoms are the result in nasal congestion, due to Grass Pollen cause of a chain reaction that leads the mast cells in these tissues to release histamine, causing dilation of many small blood vessels in the nose and swelling to nasal pathway of which can affects the daily activity including quality of life, productivity, and other chronic conditions, including asthma. of which can affects the daily activity including quality of life, productivity, and other chronic conditions, including asthma.
In the study of "Bronchial Allergen Challenge Using the Medicaid Dosimeter" by Schulze J, Rosewich M, Dressler M, Riemer C, Rose MA, Zielen S. (Source from Department of Allergy, Pulmonology and Cystic Fibrosis, Children's Hospital, Goethe-University, Frankfurt a.M., Germany. posted in PubMed, researchers suggested that The use of aerosol provocation system to calculate the PD(20)FEV(1) allergen is a time saving procedure and is less prone to errors because only one dilution of the allergen is used. The repeatability in well-defined subjects is excellent to study the mechanisms of allergen-induced airway inflammation and the development of new treatments for allergic diseases.
and
1. Asthma-like symptoms
2. Itching
3. Sneezing
4. Wheezing
5. Sinus pain
6. Tearing eyes
7. Runny nose
8. Itchy eyes and throat 9. Etc.
F.3. Diagnosis
If you are experience Allergic Rhinitis, it is possible to find what types of allergen have trigger that. After recording the family history and a complete physical exam. you doctor may order
1. Skin test
a. Intradermal test
It is one of most common test but time consuming( some patient may return for more 20 time for the injection) in diagnosis of allergy and depending to the symptoms, by injecting small amounts of diluted allergens into the top layers of the skin to see how the immune system react to them.
b. Skin prick testing
Similar to the Intradermal test, but the diagnosis involves in applying a drop of allergen into to punctures made on the skin.
2. Blood test ((RadioAllergoSorbent Test)
This is the test for evaluating of the levels of IgE-mediated food allergies react to a particular allergen. If you RAST score is higher than the predictive value for that food, 95% chance you will have an allergic reaction. Unfortunately, non-IgE mediated allergies cannot be detected by this method.
3. Challenge Tests
Because of the risk of anaphylaxis, most doctors will avoid the test unless it is absolutely necessary and the test is performed only in the hospital. In this test, suspected allergen package into capsule taken by patient and signs or symptoms of an allergic reaction are observed.
4. Etc.
F.4. Prevention
Grass Pollen Allergy grass pollen levels can be affected by temperature, time of day, rain, etc.. There is no way to prevent them even if you want to lock your self away from the season. But one can always enhance the immune system by eating healthy and living a healthy lifestyle. For more information of healthy foods, visit 100+ Healthy Foods Classification
F.5. Treatments
F.5.1. Conventional medicine
According to the "Treatment of allergic rhinitis." American Family Physician - Volume 81, Issue 12 (June 2010), posted in MD preview, the writer wrote that allergic rhinitis is a common chronic respiratory illness that affects quality of life, productivity, and other comorbid conditions, including asthma. Treatment should be based on the patient's age and severity of symptoms. Patients should be advised to avoid known allergens and be educated about their condition. Intranasal corticosteroids are the most effective treatment and should be first-line therapy for mild to moderate disease. Moderate to severe disease not responsive to intranasal corticosteroids should be treated with second-line therapies, including antihistamines, decongestants, cromolyn, leukotriene receptor antagonists, and nonpharmacologic therapies (e.g., nasal irrigation). With the exception of cetirizine, second-generation antihistamines are less likely to cause sedation and impair performance. Immunotherapy should be considered in patients with a less than adequate response to usual treatments. Evidence does not support the use of mite-proof impermeable covers, air filtration systems, or delayed exposure to solid foods in infancy.
1. There is no specific treatment for Hay fever, but depending to the symptoms. Medication includes bronchodilators, anti-allergics, antihistamines, NSAIDs, etc.
2. Allergic shot
Allergy shot, also known as immunotherapy, contains extracts from the most common substance which people are allergic to, including pollen, insects, pets, etc., by providing long-term relief from certain symptoms. In some people, after series of allergic shot, the disease is cured.
F.5.2. Nutritional supplements
1. Antioxidants
Since Allergies are caused by immune over reaction of certain harmless substance, enhancing immue system is one of the best way to prevent and treat them as some researchers suggested that allergies may be caused by weakened immune system over aggression. Vitamin A, E, C are antioxidants and free radical scavengers, they protect the immune system from free radicals attack and help to reduce levels of histamine in the blood. For more information of antioxidants and health effects
2. Vitamin D
According to the article " Vitamin D deficiency may be a factor in development of allergies posted in Washing Post, Monday, March, 7, 2011, " Allergies and Vitamin D, Youths low in 'sunshine vitamin' may be more prone to allergies",the author wrote that analyzed data on 6,590 people, roughly half of them 21 years of age and younger and half older. The group was deemed representative of the U.S. population. Vitamin D levels were determined by blood tests, as was sensitivity to 17 common allergens. Among the youths, food and environmental allergies were greater in those with lower levels of Vitamin D. Young people deficient in Vitamin D were about twice as likely as those with higher levels of the nutrient to have peanut or ragweed allergies and nearly five times as likely to be allergic to oak.
3. B-complex
in a study of "Vitamin B-6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults." by Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN., USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111. posted in US National Library of Medicine National Institutes of Health, researchers found that Vitamin B-6 deficiency impairs in vitro indices of cell-mediated immunity in healthy elderly adults. This impairment is reversible by vitamin B-6 repletion.
4. Coenzyme Q10
It is an immune and nervous system enhancer, according to the article of "CoQ10 Helps the Immune System and Brain Function" by A.S. Gissen, posted in Immunesupport.com, the author wrote that In 1970, it was first reported that CoQ6 and CoQ10, when administered to rats, significantly enhanced immune cells' ability to kill bacteria, as well as elevated their antibody response.
5. Alpha lipoic acid
Alpha lipoic acid is another antioxidant which promotes the immune system by enhabcing the function of other antioxidants such as vitamin C, E, glutathione, etc. according to the article of "A relatively unknown antioxidant, alpha-lipoic acid, may be more potent than vitamins C and E" by Robert Sander, the author wrote that Because both alpha-lipoic acid and dihydrolipoic acid are antioxidants, their combined actions give them greater antioxidant potency than any natural antioxidant now known, Packer says. He notes another property of alpha-lipoic acid that makes it a great antioxidant. Since it is soluble in both water and fat, it can move into all parts of the cell to neutralize free radicals. Vitamin C, on the other hand, is limited to the watery parts of cells because it is soluble only in water; while vitamin E is soluble only in fat and sticks to the fatty parts of cells.
7. Etc.
F.5.3. Herbs
1.
In a study of "Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice." by
Sumiyoshi M, Sakanaka M, Kimura Y. (Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan.) posted in US National Library of Medicine National Institutes of Health, researchers suggested that It may also protect against sensitization to antigens as an immunomodulator by increasing intestinal IgA secretion without affecting antigen-specific IgE levels. In conclusion, Red Ginseng roots may be a natural preventative of food allergies.
2. GarlicIt is best known for treating cold and flu and enhances immune system against alll types of foreign invasion. According to the study of "Immunomodulatory Effects of Aged Garlic Extract" Eikai Kyo, Naoto Uda, Shigeo Kasuga and Yoichi Itakur, Posted in the "Journal of Nutrition" in March 2001, researchers strongly suggest that AGE (Aged Garlic Extract) could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.
3. Turmeric
Turmeric paste has been used in traditional herbal medicine as an antimicrobial and anti-inflammatory agent, it also helps to treat allergy. According to an article "Vitamin D and turmeric for allergies" by Joe Graedon and Teresa Graedon posted in Washington Post, May 11-2009, the authors wrote that In animal studies, turmeric prevents the release of histamine from mast cells (Molecular Nutrition and Food Research, September 2008). If it works similarly in humans, this would prevent allergy symptoms from developing.
4. Butterbur
Has been used over thousand of years in herbal medicine in treating symptoms of allergy, including to treat coughs,, asthma, stress, muscle relaxant, etc..According to the article of "Allergy" posted in The University of Michigan health System, the article indicated Two double-blind studies have compared butterbur extract to standard antihistamine drugs in people with hay fever. The first compared it with the drug cetirizine (Zyrtec) and found the drug and butterbur extract relieved symptoms equally well. However, cetirizine caused significantly more adverse effects, including a high rate of drowsiness.4 The second study compared butterbur extract with fexofenadine (Allegra) and placebo. Butterbur extract was as effective as fexofenadine at relieving symptoms, and both were significantly better than placebo.
5. Etc.
F.5.4. Traditional Chinese medicine
In a study of "Complementary and alternative medicine in pediatric allergic disorders." by Li XM. (Source from Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA., posted in PubMed, researcher indicated that in the last 2-3 years, there have been more controlled studies of TCM for allergic asthma and allergic rhinitis. Several publications including ours indicate that some TCM herbal formulas are well tolerated and produce some level of efficacy. Some herbal formulas also showed beneficial immunomodualtory effects. Several preclinical studies demonstrated that the food allergy herbal formula-2 was effective in protecting against peanut anaphylaxis in animal models. Two TCM products have entered clinical trials in the United States for treating asthma and food allergy, respectively. Both of these trials include children. In Summary, researcher concluded that Recent studies indicate that TCM therapy including herbal medicines and acupuncture for allergic disorders in children is well tolerated. There are also promising clinical and objective improvements. More controlled clinical studies are encouraged.
1. Xin Yi Hua is a lily-shaped flower with a hairy bud and Xin-yi-san (Magnolia Flower Powder)
a. It is a type of traditional Chinese medicine used to treat allergy and dramatically reduces the symptoms of sneezing, anosmia, nasal congestion and profuse rhinorrhea (runny nose) caused by allergies triggered by dust mites, pets and fungi.
According to the study of "Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects" by
Sien-Hung Yang, Chia-Li Yu, Ying-Lin Chen, Sheng-Lin Chiao, Mei-Ling Chen f. Posted in International Immunopharmacology 10 (2010) 951–958, researchers found that this proposal is based on the fact that different combinations of Chinese herbs involve different mechanisms. It appears that the immunosuppressive and anti-inflammatory effects derived from the mixed formula of Chinese herbs are broader than XYS. Nevertheless,we found that XYS alone sufficiently exerts immunomodulatory effects on patients with AR.
In conclusion, this study provides evidence to support that XYS, when used singly, is beneficial in nasal allergic inflammation through enhancing IL-10 and IL-8 production.
b. Ingredient
Main use: Expels wind-cold, unblocks nasal passages, congestion, loss of smell, sinus headache.
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Wednesday, September 14, 2011
Obesity and Impotence
A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Impotence is classified as a condition of erectile dysfunction of male with characteristic of inability maintain an erection of the penis during sexual intercourse.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Impotence
1. In a study of "Obesity and sexual dysfunction, male and female" by Esposito K, Giugliano F, Ciotola M, De Sio M, D'Armiento M, Giugliano D" ( from Source Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy. katherine.esposito@unina2.it, Int J Impot Res. 2008 Jul-Aug;20(4):358-65. Epub 2008 Apr 10), posted in PubMed, researchers stated that
a. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic.
b. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED.
2. According to the abstract of study of "Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction" by Traish AM, Feeley RJ, Guay A. (Source from Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA. atraish@bu.edu, FEBS J. 2009 Oct;276(20):5755-67. Epub 2009 Sep 15), posted in PubMed, researchers found that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, contributing to hypogandism and erectile dysfunction. Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity.
3. According to the study of "Androgen deficiency and abnormal penile duplex parameters in obese men with erectile dysfunction" by Zohdy W, Kamal EE, Ibrahim Y. (Source from University of Cairo, Department of Andrology, Cairo, Egypt. wzohdy62@hotmail.com, J Sex Med. 2007 May;4(3):797-808), posted in PubMed, researchers indicated that Obesity is associated with lower TT and disturbances of penile hemodynamics. It is an independent clinical factor for vasculogenic ED.
4. In a study of "Obesity, low testosterone levels and erectile dysfunction" by Diaz-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. (Source from Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90803, USA.Int J Impot Res. 2009 Mar-Apr;21(2):89-98. Epub 2008 Oct 9), researchers found that the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus.
5. According to the abstract of study of "Complications of a buried penis in an extremely obese patient" by Mattsson B, Vollmer C, Schwab C, Padevit C, Horton K, John H, Horstmann M. (Source from Department of Urology, Kantonsspital Winterthur, Winterthur, Switzerland.© 2011 Blackwell Verlag GmbH), posted in PubMed, researchers concluded that Whereas acute complications of a buried penis in obese patients include local infection and urinary retention, chronic problems are undirected voiding, disturbed vaginal penetration and erectile dysfunction. Even though several surgical techniques are described, weight reduction should be primarily preferred.
6. In a study of "Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction" by Corona G, Rastrelli G, Monami M, Melani C, Balzi D, Sforza A, Forti G, Mannucci E, Maggi M. (Source from Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy, © 2011 International Society for Sexual Medicine.), posted in PubMed, researchers found that Hypogonadism-associated CV risk depends on the characteristics of subjects, being more evident in normal weight than in obese patients. Further studies are advisable to clarify if low T in obese patients is a (positive) consequence of a comorbid condition (i.e., to save energy) or if it represents a pathogenetic issue of the same illness. Hence, possible misuse/abuse of T treatment in obese subjects must be avoided.
7. Etc.
E.Treatments of Obesity and Impotence
1. According to the study of "The importance of risk factor reduction in erectile dysfunction" by
Jackson G. (Source from Cardiothoracic Centre, 6th floor, East Wing, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom. gjcardiol@talk21.com, Curr Urol Rep. 2007 Nov;8(6):463-6.), posted in PubMed, researchers Intensive intervention with lifestyle advice focusing on a healthy diet, weight loss, and increased physical activity benefits men with ED, reducing the markers of inflammation and improving endothelial function. Though phosphodiesterase type 5 inhibitors are highly effective in treating ED, lifestyle advice and aggressive risk reduction remain fundamental to the overall vascular good health of the individual.
2. In a study of "Beneficial impact of exercise and obesity interventions on erectile function and its risk factors" by Hannan JL, Maio MT, Komolova M, Adams MA. (Source fromDepartment of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada,J Sex Med. 2009 Mar;6 Suppl 3:254-61), posted in PubMed, the result showed that Physical inactivity negatively impacts on erectile function, and experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health. Mediterranean-style diets and a reduction in caloric intake have been found to improve erectile function in men with the aspects of the metabolic syndrome. In addition, both clinical and experimental studies have confirmed that combining the two interventions provides additional benefit to erectile function, likely via reduced metabolic disturbances (e.g., inflammatory markers, insulin resistance), decreased visceral adipose tissue, and improvement in vascular function (e.g., increased endothelial function), researchers concluded that Lifestyle modifications provide significant benefits to vascular health and erectile function in a population that is increasingly aged and more obese.
3. In an abstract of the study of "Physical activity and erectile dysfunction in middle-aged men : a brief review" by La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero A. (J Androl. 2011 May 19. [Epub ahead of print]), posted in PubMed researchers found that Conflicting data regarding the effects of exercise on the androgen status. In clinical practice would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
B. Impotence is classified as a condition of erectile dysfunction of male with characteristic of inability maintain an erection of the penis during sexual intercourse.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Impotence
1. In a study of "Obesity and sexual dysfunction, male and female" by Esposito K, Giugliano F, Ciotola M, De Sio M, D'Armiento M, Giugliano D" ( from Source Division of Metabolic Diseases, Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Naples, Italy. katherine.esposito@unina2.it, Int J Impot Res. 2008 Jul-Aug;20(4):358-65. Epub 2008 Apr 10), posted in PubMed, researchers stated that
a. Overweight and obesity may increase the risk of erectile dysfunction (ED) by 30-90% as compared with normal weight subjects. On the other hand, subjects with ED tend to be heavier and with a greater waist than subjects without ED, and also are more likely to be hypertensive and hypercholesterolemic.
b. The metabolic syndrome, characterized by a clustering of risk factors associated with insulin resistance and abdominal obesity, associates with ED.
2. According to the abstract of study of "Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction" by Traish AM, Feeley RJ, Guay A. (Source from Department of Biochemistry and Urology, Boston University School of Medicine, MA 02118, USA. atraish@bu.edu, FEBS J. 2009 Oct;276(20):5755-67. Epub 2009 Sep 15), posted in PubMed, researchers found that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, contributing to hypogandism and erectile dysfunction. Thus, clinical screening for the risk of erectile dysfunction in obese patients should include the assessment of waist circumference, testosterone levels, body mass index and physical inactivity.
3. According to the study of "Androgen deficiency and abnormal penile duplex parameters in obese men with erectile dysfunction" by Zohdy W, Kamal EE, Ibrahim Y. (Source from University of Cairo, Department of Andrology, Cairo, Egypt. wzohdy62@hotmail.com, J Sex Med. 2007 May;4(3):797-808), posted in PubMed, researchers indicated that Obesity is associated with lower TT and disturbances of penile hemodynamics. It is an independent clinical factor for vasculogenic ED.
4. In a study of "Obesity, low testosterone levels and erectile dysfunction" by Diaz-Arjonilla M, Schwarcz M, Swerdloff RS, Wang C. (Source from Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90803, USA.Int J Impot Res. 2009 Mar-Apr;21(2):89-98. Epub 2008 Oct 9), researchers found that the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus.
5. According to the abstract of study of "Complications of a buried penis in an extremely obese patient" by Mattsson B, Vollmer C, Schwab C, Padevit C, Horton K, John H, Horstmann M. (Source from Department of Urology, Kantonsspital Winterthur, Winterthur, Switzerland.© 2011 Blackwell Verlag GmbH), posted in PubMed, researchers concluded that Whereas acute complications of a buried penis in obese patients include local infection and urinary retention, chronic problems are undirected voiding, disturbed vaginal penetration and erectile dysfunction. Even though several surgical techniques are described, weight reduction should be primarily preferred.
6. In a study of "Body mass index regulates hypogonadism-associated CV risk: results from a cohort of subjects with erectile dysfunction" by Corona G, Rastrelli G, Monami M, Melani C, Balzi D, Sforza A, Forti G, Mannucci E, Maggi M. (Source from Sexual Medicine and Andrology Unit, University of Florence, Florence, Italy, © 2011 International Society for Sexual Medicine.), posted in PubMed, researchers found that Hypogonadism-associated CV risk depends on the characteristics of subjects, being more evident in normal weight than in obese patients. Further studies are advisable to clarify if low T in obese patients is a (positive) consequence of a comorbid condition (i.e., to save energy) or if it represents a pathogenetic issue of the same illness. Hence, possible misuse/abuse of T treatment in obese subjects must be avoided.
7. Etc.
E.Treatments of Obesity and Impotence
1. According to the study of "The importance of risk factor reduction in erectile dysfunction" by
Jackson G. (Source from Cardiothoracic Centre, 6th floor, East Wing, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, United Kingdom. gjcardiol@talk21.com, Curr Urol Rep. 2007 Nov;8(6):463-6.), posted in PubMed, researchers Intensive intervention with lifestyle advice focusing on a healthy diet, weight loss, and increased physical activity benefits men with ED, reducing the markers of inflammation and improving endothelial function. Though phosphodiesterase type 5 inhibitors are highly effective in treating ED, lifestyle advice and aggressive risk reduction remain fundamental to the overall vascular good health of the individual.
2. In a study of "Beneficial impact of exercise and obesity interventions on erectile function and its risk factors" by Hannan JL, Maio MT, Komolova M, Adams MA. (Source fromDepartment of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada,J Sex Med. 2009 Mar;6 Suppl 3:254-61), posted in PubMed, the result showed that Physical inactivity negatively impacts on erectile function, and experimental and clinical exercise interventions have been shown to improve sexual responses and overall cardiovascular health. Mediterranean-style diets and a reduction in caloric intake have been found to improve erectile function in men with the aspects of the metabolic syndrome. In addition, both clinical and experimental studies have confirmed that combining the two interventions provides additional benefit to erectile function, likely via reduced metabolic disturbances (e.g., inflammatory markers, insulin resistance), decreased visceral adipose tissue, and improvement in vascular function (e.g., increased endothelial function), researchers concluded that Lifestyle modifications provide significant benefits to vascular health and erectile function in a population that is increasingly aged and more obese.
3. In an abstract of the study of "Physical activity and erectile dysfunction in middle-aged men : a brief review" by La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero A. (J Androl. 2011 May 19. [Epub ahead of print]), posted in PubMed researchers found that Conflicting data regarding the effects of exercise on the androgen status. In clinical practice would be recommended to add regular physical activity to balanced diet and drugs to achieve better therapeutic results.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
Obesity and Infertility
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
Infertility is defined as a condition of the female partner who can not get pregnant after 12 months of unprotected sexual intercourse.
How do calculate your BMI index
BMI= weight (kg)/ height (m2)
How obesity associates with Infertility
1. Hormonal effects
In a study of " Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic." by Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. (Source from Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. jchavarr@hsph.harvard.edu, Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.), posted in PubMed, using the Standard semen analysis, sperm DNA fragmentation, and serum levels of reproductive hormones, researchers found that despite major differences in reproductive hormone levels with increasing body weight, only extreme levels of obesity may negatively influence male reproductive potential.
2. Sperm concentration and total sperm count
According to the study of " Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?" by Aggerholm AS, Thulstrup AM, Toft G, Ramlau-Hansen CH, Bonde JP. (Source from Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. ansag@as.aaa.dk), posted in PubMed, researchers found that The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E(2) concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men and suggested that that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.
3. Egg quality
In a stidu of " The impact of obesity on egg quality" by Purcell SH, Moley KH. (Source from Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., St. Louis, MO, 63110, USA), posted in PubMed, researchers found that Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations
4. Ovarian structure and function
In a study of " The New Zealand obese mouse model of obesity insulin resistance and poor breeding performance: evaluation of ovarian structure and function" by Radavelli-Bagatini S, Blair AR, Proietto J, Spritzer PM, Andrikopoulos S. (Source from Department of Medicine (Austin Health/Northern Health), Heidelberg Repatriation Hospital, The University of Melbourne, Heidelberg Heights, Melbourne, Victoria 3081, Australia), researchers concluded that NZO mice (New Zealand obese mice) show a poor breeding performance due to decreased ovulation, increased number of primordial and atretic follicles, and ovarian size. Given that NZO mice are obese, hyperinsulinemic and insulin resistant, they are suitable for investigating pathophysiological mechanisms linking metabolic alterations with reproductive defects.
5. Ovarian dysfunction
According to the study of "Inflammatory pathways linking obesity and ovarian dysfunction" by
Infertility is defined as a condition of the female partner who can not get pregnant after 12 months of unprotected sexual intercourse.
How do calculate your BMI index
BMI= weight (kg)/ height (m2)
How obesity associates with Infertility
1. Hormonal effects
In a study of " Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic." by Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. (Source from Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. jchavarr@hsph.harvard.edu, Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.), posted in PubMed, using the Standard semen analysis, sperm DNA fragmentation, and serum levels of reproductive hormones, researchers found that despite major differences in reproductive hormone levels with increasing body weight, only extreme levels of obesity may negatively influence male reproductive potential.
2. Sperm concentration and total sperm count
According to the study of " Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?" by Aggerholm AS, Thulstrup AM, Toft G, Ramlau-Hansen CH, Bonde JP. (Source from Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark. ansag@as.aaa.dk), posted in PubMed, researchers found that The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E(2) concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men and suggested that that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.
3. Egg quality
In a stidu of " The impact of obesity on egg quality" by Purcell SH, Moley KH. (Source from Department of Obstetrics and Gynecology, Washington University in St. Louis, 660 South Euclid Ave., St. Louis, MO, 63110, USA), posted in PubMed, researchers found that Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations
4. Ovarian structure and function
In a study of " The New Zealand obese mouse model of obesity insulin resistance and poor breeding performance: evaluation of ovarian structure and function" by Radavelli-Bagatini S, Blair AR, Proietto J, Spritzer PM, Andrikopoulos S. (Source from Department of Medicine (Austin Health/Northern Health), Heidelberg Repatriation Hospital, The University of Melbourne, Heidelberg Heights, Melbourne, Victoria 3081, Australia), researchers concluded that NZO mice (New Zealand obese mice) show a poor breeding performance due to decreased ovulation, increased number of primordial and atretic follicles, and ovarian size. Given that NZO mice are obese, hyperinsulinemic and insulin resistant, they are suitable for investigating pathophysiological mechanisms linking metabolic alterations with reproductive defects.
5. Ovarian dysfunction
According to the study of "Inflammatory pathways linking obesity and ovarian dysfunction" by
Robker RL, Wu LL, Yang X. (Source from School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia. rebecca.robker@adelaide.edu.au, Copyright © 2011 Elsevier Ireland Ltd. All rights reserved), posted in PubMed, researchers found that Studies in mice support this and allow further dissection of the pathways by which diet-induced obesity contributes to changes in mitochondria and the endoplasmic reticulum. These studies are in their infancy but cumulatively provide basic information about the cellular mechanisms that may lead to the impaired ovulation and reduced oocyte developmental potential that is observed in obese females.
6. Pregnancy-related complications
According to the study "Effect of body mass index on in vitro fertilization outcomes in women" by Sathya A, Balasubramanyam S, Gupta S, Verma T. (Source from Consultant Endocrinologist, Institute of Reproductive Medicine and Women's Health, Madras Medical Mission Hospital, Chennai, Tamil Nadu, India), posted in PobMed, researchers concluded in abstract that Increase in body mass index in women does not appear to have an adverse effect on IVF outcome. However, preconceptual counselling for obese women is a must as weight reduction helps in reducing pregnancy-related complications.
7. Etc.
Effect of Female obesity and Newborn
In a study of "[Obesity and female reproduction].[Article in French], by Sarfati J, Young J, Christin-Maitre S. (Source from Service d'Endocrinologie et des Maladies de la Reproduction, Centre Hospitalier Universitaire de Bicêtre - APHP, 78 rue du Général-Leclerc 94275 Le Kremlin-Bicêtre, France. sarfati_julie@yahoo.fr, Copyright © 2010 Elsevier Masson SAS. All rights reserved), posted in PobMed, researchers found that In this model, all weaned pups have been fed with a regular diet. At 13 weeks, pups delivered from obese mice were significantly larger, and these pups demonstrated early development of a metabolic-type syndrome. These findings suggest that maternal obesity has adverse effects as early as the oocyte and preimplantation embryo stages and that these effects may contribute to lasting morbidity in offspring, underscoring the importance of optimal maternal weight and nutrition before conception.
The importance of Obesity and Infertility treatment
1. According to the study of "Impact of obesity on female fertility and fertility treatment" by Zain MM, Norman RJ. (Source from University of Adelaide, Research Centre for Reproductive Health, School of Paediatrics & Reproductive Health, South Australia, Australia. murizah.mohdzain@adelaide.edu.au), posted in PubMed, researchers filed in abstract that treatment of obesity itself should be the initial aim in obese infertile women before embarking on ovulation-induction drugs or assisted reproductive techniques. While various strategies for weight reduction, including diet, exercise, pharmacological and surgical intervention exist, lifestyle modification continues to be of paramount importance.
2. In a study of "Improving reproductive performance in overweight/obese women with effective weight management" by Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX. (Source from Reproductive Medicine Unit, University of Adelaide, The Queen Elizabeth Hospital, Woodville Rd, Woodville, SA5011, Australia_, posted in PubMed, researchers found that weight loss can improve the fertility of obese women through the recovery of spontaneous ovulation, whereas others will have improved response to ovarian stimulation in infertility treatment. Therefore, it is proposed that following the initial assessment of infertility and body mass index or other measurement of obesity, various weight management interventions, including diet, exercise or pharmacotherapeutic approaches, should be considered for overweight and obese infertile women.
3. Reported from the study of "The obese patient with infertility: a practical approach to diagnosis and treatment" by Moran LJ, Norman RJ. (Source from Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, South Australia, Australia), posted in Pubmed, researchers found that weight loss should be promoted as an initial treatment option for obese women with infertility. However, the most effective method for achieving and maintaining weight loss is unclear. Gradual weight loss is best achieved through a sensible eating plan that can be maintained over long periods of time. The likelihood of maintaining weight loss is increased when diet is combined with regular exercise, cognitive behavior therapy, and a supportive group environment. Adoption of these principles in a primary healthcare setting can therefore aid in treatment of infertility related to obesity.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
6. Pregnancy-related complications
According to the study "Effect of body mass index on in vitro fertilization outcomes in women" by Sathya A, Balasubramanyam S, Gupta S, Verma T. (Source from Consultant Endocrinologist, Institute of Reproductive Medicine and Women's Health, Madras Medical Mission Hospital, Chennai, Tamil Nadu, India), posted in PobMed, researchers concluded in abstract that Increase in body mass index in women does not appear to have an adverse effect on IVF outcome. However, preconceptual counselling for obese women is a must as weight reduction helps in reducing pregnancy-related complications.
7. Etc.
Effect of Female obesity and Newborn
In a study of "[Obesity and female reproduction].[Article in French], by Sarfati J, Young J, Christin-Maitre S. (Source from Service d'Endocrinologie et des Maladies de la Reproduction, Centre Hospitalier Universitaire de Bicêtre - APHP, 78 rue du Général-Leclerc 94275 Le Kremlin-Bicêtre, France. sarfati_julie@yahoo.fr, Copyright © 2010 Elsevier Masson SAS. All rights reserved), posted in PobMed, researchers found that In this model, all weaned pups have been fed with a regular diet. At 13 weeks, pups delivered from obese mice were significantly larger, and these pups demonstrated early development of a metabolic-type syndrome. These findings suggest that maternal obesity has adverse effects as early as the oocyte and preimplantation embryo stages and that these effects may contribute to lasting morbidity in offspring, underscoring the importance of optimal maternal weight and nutrition before conception.
The importance of Obesity and Infertility treatment
1. According to the study of "Impact of obesity on female fertility and fertility treatment" by Zain MM, Norman RJ. (Source from University of Adelaide, Research Centre for Reproductive Health, School of Paediatrics & Reproductive Health, South Australia, Australia. murizah.mohdzain@adelaide.edu.au), posted in PubMed, researchers filed in abstract that treatment of obesity itself should be the initial aim in obese infertile women before embarking on ovulation-induction drugs or assisted reproductive techniques. While various strategies for weight reduction, including diet, exercise, pharmacological and surgical intervention exist, lifestyle modification continues to be of paramount importance.
2. In a study of "Improving reproductive performance in overweight/obese women with effective weight management" by Norman RJ, Noakes M, Wu R, Davies MJ, Moran L, Wang JX. (Source from Reproductive Medicine Unit, University of Adelaide, The Queen Elizabeth Hospital, Woodville Rd, Woodville, SA5011, Australia_, posted in PubMed, researchers found that weight loss can improve the fertility of obese women through the recovery of spontaneous ovulation, whereas others will have improved response to ovarian stimulation in infertility treatment. Therefore, it is proposed that following the initial assessment of infertility and body mass index or other measurement of obesity, various weight management interventions, including diet, exercise or pharmacotherapeutic approaches, should be considered for overweight and obese infertile women.
3. Reported from the study of "The obese patient with infertility: a practical approach to diagnosis and treatment" by Moran LJ, Norman RJ. (Source from Reproductive Medicine Unit, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, South Australia, Australia), posted in Pubmed, researchers found that weight loss should be promoted as an initial treatment option for obese women with infertility. However, the most effective method for achieving and maintaining weight loss is unclear. Gradual weight loss is best achieved through a sensible eating plan that can be maintained over long periods of time. The likelihood of maintaining weight loss is increased when diet is combined with regular exercise, cognitive behavior therapy, and a supportive group environment. Adoption of these principles in a primary healthcare setting can therefore aid in treatment of infertility related to obesity.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
Obesity and Poor Healing of Wounds
A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Poor Healing of Wounds are defined as a condition of the inability of the body to heal the wound quickly. It may be caused by the physical state of the wound or certain health effects, such as obesity, diabetes, abnormal coagulation. etc.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Poor Healing of Wounds
1. According to the study of "Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity" by Taylor KR, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,J Invest Dermatol. 2011 Aug 11. doi: 10.1038/jid.2011.241. [Epub ahead of print]), posted in PubMed,, researchers found that These studies reveal that γδ T cells are unable to regulate keratinocyte homeostasis in obesity and that the obese environment further impairs skin structure by altering cell-cell adhesion. Together, impaired keratinocyte homeostasis and epidermal barrier function through direct and indirect mechanisms result in susceptibility to skin complications, chronic wounds, and infection.
2. In a study of "Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease" by Taylor KR, Mills RE, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, PLoS One. 2010 Jul 2;5(7):e11422.), posted in PubMed, researchers filed in abstract that Skin gammadelta T cells that overcome this hyperglycemic state are unresponsive to epithelial cell damage due to chronic inflammatory mediators, including TNFalpha. Cytokine and growth factor production at the site of tissue damage was partially restored by administering neutralizing TNFalpha antibodies in vivo. Thus, metabolic disease negatively impacts homeostasis and functionality of skin gammadelta T cells, rendering host defense mechanisms vulnerable to injury and infection.
3. In an abstract of the study of "Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study" by Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, Goren I. (Source from Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany), posted in PubMed, researchers found that by contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
4. According to the study of "Impaired Laparotomy Wound Healing in Obese Rats" by Xing L, Culbertson EJ, Wen Y, Robson MC, Franz MG. (Source from Department of Surgery, University of Michigan, 2124F Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-0331, USA), posted in PubMed, researchers indicated that laparotomy wound healing is impaired in obese rats. The recovery of laparotomy wound strength is delayed due to abnormal collagen maturation and remodeling, possibly due to a defect in fibroblast function. Strategies to improve outcomes for laparotomy wound healing in obese patients should include correcting the wound healing defect, possibly with growth factor or cell therapy.
5. Etc.
E. Treatments of Obesity and Poor Healing of Wounds
1. According to the abstract of the study of "Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity" by Slavkovsky R, Kohlerova R, Tkacova V, Jiroutova A, Tahmazoglu B, Velebny V, Rezačová M, Sobotka L, Kanta J. (Source from Laboratory of Wound Healing, CPN, Dolni Dobrouc, Czech Republic. rastik@gmail.com, Wound Repair Regen. 2011 Jul;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.), posted in PubMed, researcher indicated that The concentration of hydroxyproline in the GT of diabetic animals was significantly decreased to about one half when compared with the nondiabetic controls. The expression of interleukin-6, myeloperoxidase, stromelysin-1, and collagenase-3 was increased in the GT of diabetic rats on Day 10, while the expression of type I collagen and elastin was decreased. Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, and connective tissue turnover and are thus proposed as a new model for studying impaired repair.
2. According to the study of "Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice" by Stallmeyer B, Pfeilschifter J, Frank S. (Source from Centre of Pharmacology, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany), posted in PubMed, researchers filed in abstracted that These data suggest that leptin reconstituted epithelial expression of VEGF during skin repair in ob/ob mice but failed to improve wound angiogenesis in the granulation tissue. Thus, the accelerated wound closure observed in leptin-supplemented ob/ob mice is not coupled to an improved wound angiogenesis.
3. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
B. Poor Healing of Wounds are defined as a condition of the inability of the body to heal the wound quickly. It may be caused by the physical state of the wound or certain health effects, such as obesity, diabetes, abnormal coagulation. etc.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Poor Healing of Wounds
1. According to the study of "Dysfunctional γδ T Cells Contribute to Impaired Keratinocyte Homeostasis in Mouse Models of Obesity" by Taylor KR, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,J Invest Dermatol. 2011 Aug 11. doi: 10.1038/jid.2011.241. [Epub ahead of print]), posted in PubMed,, researchers found that These studies reveal that γδ T cells are unable to regulate keratinocyte homeostasis in obesity and that the obese environment further impairs skin structure by altering cell-cell adhesion. Together, impaired keratinocyte homeostasis and epidermal barrier function through direct and indirect mechanisms result in susceptibility to skin complications, chronic wounds, and infection.
2. In a study of "Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease" by Taylor KR, Mills RE, Costanzo AE, Jameson JM. (Source from Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America, PLoS One. 2010 Jul 2;5(7):e11422.), posted in PubMed, researchers filed in abstract that Skin gammadelta T cells that overcome this hyperglycemic state are unresponsive to epithelial cell damage due to chronic inflammatory mediators, including TNFalpha. Cytokine and growth factor production at the site of tissue damage was partially restored by administering neutralizing TNFalpha antibodies in vivo. Thus, metabolic disease negatively impacts homeostasis and functionality of skin gammadelta T cells, rendering host defense mechanisms vulnerable to injury and infection.
3. In an abstract of the study of "Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: a comparative study" by Seitz O, Schürmann C, Hermes N, Müller E, Pfeilschifter J, Frank S, Goren I. (Source from Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Johann Wolfgang Goethe-Universität, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany), posted in PubMed, researchers found that by contrast to impaired wound conditions in ob/ob mice, late wounds of HFD mice did not develop a chronic inflammatory state and were epithelialized after 11 days of repair. Thus, only genetically obese and diabetic ob/ob mice finally developed chronic wounds and therefore represent a better suited experimental model to investigate diabetes-induced wound healing disorders.
4. According to the study of "Impaired Laparotomy Wound Healing in Obese Rats" by Xing L, Culbertson EJ, Wen Y, Robson MC, Franz MG. (Source from Department of Surgery, University of Michigan, 2124F Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-0331, USA), posted in PubMed, researchers indicated that laparotomy wound healing is impaired in obese rats. The recovery of laparotomy wound strength is delayed due to abnormal collagen maturation and remodeling, possibly due to a defect in fibroblast function. Strategies to improve outcomes for laparotomy wound healing in obese patients should include correcting the wound healing defect, possibly with growth factor or cell therapy.
5. Etc.
E. Treatments of Obesity and Poor Healing of Wounds
1. According to the abstract of the study of "Zucker diabetic fatty rat: a new model of impaired cutaneous wound repair with type II diabetes mellitus and obesity" by Slavkovsky R, Kohlerova R, Tkacova V, Jiroutova A, Tahmazoglu B, Velebny V, Rezačová M, Sobotka L, Kanta J. (Source from Laboratory of Wound Healing, CPN, Dolni Dobrouc, Czech Republic. rastik@gmail.com, Wound Repair Regen. 2011 Jul;19(4):515-25. doi: 10.1111/j.1524-475X.2011.00703.x. Epub 2011 Jun 7.), posted in PubMed, researcher indicated that The concentration of hydroxyproline in the GT of diabetic animals was significantly decreased to about one half when compared with the nondiabetic controls. The expression of interleukin-6, myeloperoxidase, stromelysin-1, and collagenase-3 was increased in the GT of diabetic rats on Day 10, while the expression of type I collagen and elastin was decreased. Taken together, Zucker diabetic fatty rats exhibited impairments in wound-size reduction, inflammatory response, tissue organization, and connective tissue turnover and are thus proposed as a new model for studying impaired repair.
2. According to the study of "Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice" by Stallmeyer B, Pfeilschifter J, Frank S. (Source from Centre of Pharmacology, University Hospital, Johann Wolfgang Goethe University, Frankfurt am Main, Germany), posted in PubMed, researchers filed in abstracted that These data suggest that leptin reconstituted epithelial expression of VEGF during skin repair in ob/ob mice but failed to improve wound angiogenesis in the granulation tissue. Thus, the accelerated wound closure observed in leptin-supplemented ob/ob mice is not coupled to an improved wound angiogenesis.
3. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
Obesity and Prostate Cancer
Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. For more information of prostate cancer, visit http://thecancerhealingguide.blogspot.com/2011/06/most-common-types-of-cancer-prostate.html
C. Prostate enlargement is defined as condition of increasing of the levels of the by-product prolactin of testosterone of men, that stimulates the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT, triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT.
D. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
E. How Obesity associates with Prostate Cancer
1. According to the abstract of the study of "Abdominal obesity as risk factor for prostate cancer diagnosis and high grade disease: A prospective multicenter Italian cohort study" by De Nunzio C, Albisinni S, Freedland SJ, Miano L, Cindolo L, Finazzi Agrò E, Autorino R, De Sio M, Schips L, Tubaro A. Source from Urol Oncol. 2011 Sep 16. [Epub ahead of print]), posted in PubMed, researchers indicated that Obesity defined by BMI and WC seems to be associated with CaP and, more specifically, with high-grade disease at the time of biopsy. The relationship between obesity and CaP is complex and remains to be further addressed.
2. In a study of "Metabolic syndrome is associated with high grade gleason score when prostate cancer is diagnosed on biopsy" by De Nunzio C, Freedland SJ, Miano R, Trucchi A, Cantiani A, Carluccini A, Tubaro A. (Source from Department of Urology, Ospedale Sant'Andrea, University "La Sapienza," Roma, Italy. cosimodenunzio@virgilio.it. Copyright © 2011 Wiley-Liss, Inc.), posted in PubMed, the result indicated that one hundred ninety five patients were enrolled with a median age and PSA of 69 years and 5.6 ng/ml respectively. Median BMI was 27.6 kg/m(2) with 64 patients (33%) being classified as obese (BMI ≥ 30 kg/m(2) ). Eighty-six patients (44%) had MS. Eighty-three patients (43%) had cancer on biopsy; 37 (45%) with MS and 46 (55%) without (P = 0.48). PSA was independently associated with higher risk of cancer (OR 1.12/1 U PSA, P = 0.01). Out of 83 patients with prostate cancer, 42 (51%) had Gleason score 6 (12 (28.5%) presented a MS) and 41 (49%) a Gleason score ≥7 (25 (61%) presented a MS). The presence of MS was not associated with an increased risk prostate cancer (OR: 0.97, P = 0.94) but with an increased risk of Gleason ≥7 (OR: 3.82; P = 0.013).
3. In an abstract of athe study of "Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study" byDiscacciati A, Orsini N, Andersson SO, Andrén O, Johansson JE, Wolk A. (Source from Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Br J Cancer. 2011 Aug 16. doi: 10.1038/bjc.2011.319. [Epub ahead of print]), posted in PubMed, researchers found that a dual association between BMI and fatal PCa - a decreased risk among men who were obese during early adulthood and an increased risk among those who were obese during middle-late adulthood.British Journal of Cancer advance online publication, 16 August 2011; doi:10.1038/bjc.2011.319 www.bjcancer.com.
4. According to the abstarct of study of "Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality" by Wright ME, Chang SC, Schatzkin A, Albanes D, Kipnis V, Mouw T, Hurwitz P, Hollenbeck A, Leitzmann MF. (Source from Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. mewright@uic.edu, Cancer. 2007 Feb 15;109(4):675-84.), posted in PubMed, researchers concluded that Although adiposity was not related positively to prostate cancer incidence, higher BMI and adult weight gain increased the risk of dying from prostate cancer.
5. According to a study of "Is obesity a risk factor for prostate cancer, and does it even matter? A hypothesis and different perspective" by Moyad MA. (Source from Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0330, USA. moyad@umich.edu, Urology. 2002 Apr;59(4 Suppl 1):41-50), posted in PUbMed, researchers found that The 2 largest prospective studies on BMI and overall mortality have also demonstrated the substantial negative impact of excess weight on society. Prostate cancer risk and obesity need further research to establish if a true association exists, but at this time, does it really matter? Overall, the profound adverse effect of being obese on general health is dramatic, and this is what clinicians and patients need to remember.
6. In abstract of study of "Inverse correlation between body mass index and clinical outcomes in men with advanced castration-recurrent prostate cancer" by Halabi S, Ou SS, Vogelzang NJ, Small EJ. (Source from Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina 27705, USA. susan.halabi@duke.edu, Cancer. 2007 Oct 1;110(7):1478-84.), posted in PubMed, researchers indicated that Approximately 24% of the patients had a normal BMI, 43% were overweight, and 33% were mildly to severely obese. On multivariable analysis, BMI was found to be a statistically significant predictor of overall survival and prostate cancer-specific mortality. Compared with men with normal BMIs, the hazard ratios for death for overweight men and mildly to severely obese men were 0.80 (95% confidence interval [95% CI], 0.68-0.93; P = .001) and 0.80 (95% CI, 0.68-0.94; P = .010), respectively.
7. Etc.
F. Treatment of Obesity and Prostate Cancer
1. According to the study of "Obesity and sex steroids during gonadotropin-releasing hormone agonist treatment for prostate cancer" by Smith MR. (Source from Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. smith.matthew@mgh.harvard.edu, Clin Cancer Res. 2007 Jan 1;13(1):241-5.), posted in PubMed, researcher concluded in abstract that Despite lower pretreatment serum testosterone levels, obese men have higher total and free testosterone levels during leuprolide treatment than men with normal BMI. These differences may contribute to the association between obesity and increased prostate cancer mortality.
2. In a study of " Influence of obesity on the incidence and treatment of genitourinary malignancies" by Stewart SB, Freedland SJ. (Source, from Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA, Copyright © 2011 Elsevier Inc. All rights reserved), posted in PubMed, researchers stated that Obesity appears to promote an increased risk of aggressive prostate cancer (CaP). This may be related, in part, to a detection bias found in obese men. Worse surgical and radiation treatment outcomes in the obese appear to be related not only to technical challenges, but also inherent tumor biology differences and more aggressive disease presentations.
3. According to the abstract of the study of "The impact of obesity on the incidence and treatment of gynecologic cancers: a review" by Modesitt SC, van Nagell JR Jr. (Source from Gynecologic Oncology Division, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center, Lucille Markey Cancer Center, 800 Rose Street, Lexington, KY 40536-0298, USA. smode2@uky.edu, Obstet Gynecol Surv. 2005 Oct;60(10):683-92), posted in Pubmed, researchers indicated that there is no current consensus regarding appropriate chemotherapy dosing in the obese patient. Obesity is a serious health problem with significant effects on the incidence and treatment of the gynecologic malignancies. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader should be able to summarize the clear evidence that obesity is a risk factor for many cancers, including gynecologic malignancies; describe the role of unopposed estrogen in gynecologic cancers; and explain that obese women overall have a poorer survival rate when afflicted with cancer.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
B. Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams. For more information of prostate cancer, visit http://thecancerhealingguide.blogspot.com/2011/06/most-common-types-of-cancer-prostate.html
C. Prostate enlargement is defined as condition of increasing of the levels of the by-product prolactin of testosterone of men, that stimulates the production of the enzyme 5-alpha reductase that causes the conversion of testosterone to gihydro-testosterones DHT, triggering prostate enlargement and other problems. Therefore in order to prevent the symptoms of enlarged prostate is to naturally impend the conversion of testosterone to DHT.
D. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
E. How Obesity associates with Prostate Cancer
1. According to the abstract of the study of "Abdominal obesity as risk factor for prostate cancer diagnosis and high grade disease: A prospective multicenter Italian cohort study" by De Nunzio C, Albisinni S, Freedland SJ, Miano L, Cindolo L, Finazzi Agrò E, Autorino R, De Sio M, Schips L, Tubaro A. Source from Urol Oncol. 2011 Sep 16. [Epub ahead of print]), posted in PubMed, researchers indicated that Obesity defined by BMI and WC seems to be associated with CaP and, more specifically, with high-grade disease at the time of biopsy. The relationship between obesity and CaP is complex and remains to be further addressed.
2. In a study of "Metabolic syndrome is associated with high grade gleason score when prostate cancer is diagnosed on biopsy" by De Nunzio C, Freedland SJ, Miano R, Trucchi A, Cantiani A, Carluccini A, Tubaro A. (Source from Department of Urology, Ospedale Sant'Andrea, University "La Sapienza," Roma, Italy. cosimodenunzio@virgilio.it. Copyright © 2011 Wiley-Liss, Inc.), posted in PubMed, the result indicated that one hundred ninety five patients were enrolled with a median age and PSA of 69 years and 5.6 ng/ml respectively. Median BMI was 27.6 kg/m(2) with 64 patients (33%) being classified as obese (BMI ≥ 30 kg/m(2) ). Eighty-six patients (44%) had MS. Eighty-three patients (43%) had cancer on biopsy; 37 (45%) with MS and 46 (55%) without (P = 0.48). PSA was independently associated with higher risk of cancer (OR 1.12/1 U PSA, P = 0.01). Out of 83 patients with prostate cancer, 42 (51%) had Gleason score 6 (12 (28.5%) presented a MS) and 41 (49%) a Gleason score ≥7 (25 (61%) presented a MS). The presence of MS was not associated with an increased risk prostate cancer (OR: 0.97, P = 0.94) but with an increased risk of Gleason ≥7 (OR: 3.82; P = 0.013).
3. In an abstract of athe study of "Body mass index in early and middle-late adulthood and risk of localised, advanced and fatal prostate cancer: a population-based prospective study" byDiscacciati A, Orsini N, Andersson SO, Andrén O, Johansson JE, Wolk A. (Source from Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden. Br J Cancer. 2011 Aug 16. doi: 10.1038/bjc.2011.319. [Epub ahead of print]), posted in PubMed, researchers found that a dual association between BMI and fatal PCa - a decreased risk among men who were obese during early adulthood and an increased risk among those who were obese during middle-late adulthood.British Journal of Cancer advance online publication, 16 August 2011; doi:10.1038/bjc.2011.319 www.bjcancer.com.
4. According to the abstarct of study of "Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality" by Wright ME, Chang SC, Schatzkin A, Albanes D, Kipnis V, Mouw T, Hurwitz P, Hollenbeck A, Leitzmann MF. (Source from Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. mewright@uic.edu, Cancer. 2007 Feb 15;109(4):675-84.), posted in PubMed, researchers concluded that Although adiposity was not related positively to prostate cancer incidence, higher BMI and adult weight gain increased the risk of dying from prostate cancer.
5. According to a study of "Is obesity a risk factor for prostate cancer, and does it even matter? A hypothesis and different perspective" by Moyad MA. (Source from Department of Urology, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0330, USA. moyad@umich.edu, Urology. 2002 Apr;59(4 Suppl 1):41-50), posted in PUbMed, researchers found that The 2 largest prospective studies on BMI and overall mortality have also demonstrated the substantial negative impact of excess weight on society. Prostate cancer risk and obesity need further research to establish if a true association exists, but at this time, does it really matter? Overall, the profound adverse effect of being obese on general health is dramatic, and this is what clinicians and patients need to remember.
6. In abstract of study of "Inverse correlation between body mass index and clinical outcomes in men with advanced castration-recurrent prostate cancer" by Halabi S, Ou SS, Vogelzang NJ, Small EJ. (Source from Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina 27705, USA. susan.halabi@duke.edu, Cancer. 2007 Oct 1;110(7):1478-84.), posted in PubMed, researchers indicated that Approximately 24% of the patients had a normal BMI, 43% were overweight, and 33% were mildly to severely obese. On multivariable analysis, BMI was found to be a statistically significant predictor of overall survival and prostate cancer-specific mortality. Compared with men with normal BMIs, the hazard ratios for death for overweight men and mildly to severely obese men were 0.80 (95% confidence interval [95% CI], 0.68-0.93; P = .001) and 0.80 (95% CI, 0.68-0.94; P = .010), respectively.
7. Etc.
F. Treatment of Obesity and Prostate Cancer
1. According to the study of "Obesity and sex steroids during gonadotropin-releasing hormone agonist treatment for prostate cancer" by Smith MR. (Source from Division of Hematology and Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. smith.matthew@mgh.harvard.edu, Clin Cancer Res. 2007 Jan 1;13(1):241-5.), posted in PubMed, researcher concluded in abstract that Despite lower pretreatment serum testosterone levels, obese men have higher total and free testosterone levels during leuprolide treatment than men with normal BMI. These differences may contribute to the association between obesity and increased prostate cancer mortality.
2. In a study of " Influence of obesity on the incidence and treatment of genitourinary malignancies" by Stewart SB, Freedland SJ. (Source, from Division of Urologic Surgery and Duke Prostate Center, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA, Copyright © 2011 Elsevier Inc. All rights reserved), posted in PubMed, researchers stated that Obesity appears to promote an increased risk of aggressive prostate cancer (CaP). This may be related, in part, to a detection bias found in obese men. Worse surgical and radiation treatment outcomes in the obese appear to be related not only to technical challenges, but also inherent tumor biology differences and more aggressive disease presentations.
3. According to the abstract of the study of "The impact of obesity on the incidence and treatment of gynecologic cancers: a review" by Modesitt SC, van Nagell JR Jr. (Source from Gynecologic Oncology Division, Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center, Lucille Markey Cancer Center, 800 Rose Street, Lexington, KY 40536-0298, USA. smode2@uky.edu, Obstet Gynecol Surv. 2005 Oct;60(10):683-92), posted in Pubmed, researchers indicated that there is no current consensus regarding appropriate chemotherapy dosing in the obese patient. Obesity is a serious health problem with significant effects on the incidence and treatment of the gynecologic malignancies. TARGET AUDIENCE: Obstetricians & Gynecologists, Family Physicians. LEARNING OBJECTIVES: After completion of this article, the reader should be able to summarize the clear evidence that obesity is a risk factor for many cancers, including gynecologic malignancies; describe the role of unopposed estrogen in gynecologic cancers; and explain that obese women overall have a poorer survival rate when afflicted with cancer.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
Obesity and Colon Cancer
A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Colon Cancer or colorectal cancer is defined as a condition of the abnormal proliferation of cells in the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Colon Cancer
1. According to the study of "Colon cancer: a civilization disorder" by Watson AJ, Collins PD. (Source from Norwich Medical School, University of East Anglia, Norwich, UK. alastair.watson@uea.ac.uk, Copyright © 2011 S. Karger AG, Basel), posted in PubMed, researchers indicated in abstract that A number of these risk factors are associated with a Western lifestyle and could be considered a product of 'civilization'. Recently, smoking has been recognized as a risk factor. Energy consumption also influences colorectal cancer risk, with obesity increasing risk and exercise reducing risk. However, the strongest contribution to environmental risk for colorectal cancer is dietary. Consumption of fat, alcohol and red meat is associated with an increased risk. Fresh fruit and vegetables and dietary fibre may be protective. Much has been learnt recently about the molecular pathogenesis of colorectal cancer.
2. In a study of "Obesity and familial obesity and risk of cancer" by Hemminki K, Li X, Sundquist J, Sundquist K. (Source from Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.k.hemminki@dkfz.de, Eur J Cancer Prev. 2011 Sep;20(5):438-43.), posted in PubMed, researchers found that Family history of obesity was associated with formerly unrecognized increased risks of gallbladder and colon cancers and ocular melanoma. Cancer risks in this relatively young obese population differed quantitatively from those found after type 2 diabetes.
3. In an abstract of the study of "Body mass index influences long-term outcome in patients with colorectal cancer" by Shibakita M, Yoshimura H, Tachibana M, Ueda S, Nagasue N. (Source from
Department of Surgery, Kawasaki Hospital, Higashiyama-cho 3-3-1, Hyogo-ku, Kobe, Hyogo 652-0042, Japan. shibakita_muneaki@kawasaki-hospital-kobe.or.jp, Hepatogastroenterology. 2010 Jan-Feb;57(97):62-9), posted in PubMed, researchers found that both high and low BMI became independent prognostic factors of disease recurrence in patients with colorectal carcinoma, as low BMI was correlated with tumor progression and high BMI influenced the number of lymph node dissected.
4. in a study of "Body size, weight change, and risk of colon cancer" by Bassett JK, Severi G, English DR, Baglietto L, Krishnan K, Hopper JL, Giles GG. (Source from Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia. julie.bassett@cancervic.org.au, Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2978-86. Epub 2010 Sep 24.), posted in PubMed, researchers found that Adult weight change was positively associated with colon cancer risk for men (HR, 1.11 per 5-kg increment; 95% CI, 1.03-1.20), but not women (HR, 1.00; 95% CI, 0.94-1.07). Men who gained ≥20 kg from age 18 had an increased risk of colon cancer compared with men whose weight was stable (HR, 1.47; 95% CI, 0.94-2.31) and concluded that
Weight gain during adult life increases men's risk of colon cancer.
5. Etc.
E. Treatments of Obesity and Colon Cancer
1. according to the abstract of the study of " Colorectal cancer screening and prevention in women" by Krishnan S, Wolf JL. (Source from Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA, Womens Health (Lond Engl). 2011 Mar;7(2):213-26), posted in PubMed, researchers stated that new studies have shown other factors such as obesity and smoking to increase the risk of CRC in women. This article highlights issues unique to women with regards to CRC and outlines special considerations for determining screening intervals in women, identifies factors that make screening more difficult in women, and reviews studies that identify preventative strategies which, together with screening, may reduce the burden of CRC.
2. According to the study of "Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis" by Pendyala S, Neff LM, Suárez-Fariñas M, Holt PR. (Source from Clinical and Translational Science Center, The Rockefeller University, New York, NY 10065, USA., Am J Clin Nutr. 2011 Feb;93(2):234-42. Epub 2010 Dec 8.), posted in PubMed, researchers found that Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk.
3. According to the study of "Diet and colorectal cancer: implications for the obese and devotees of the Atkins diet" by Fleming ME, Sales KM, Winslet MC. (Source from University Department of Surgery, Royal Free and University College Medical School, Royal Free Hospital, London, UK, Colorectal Dis. 2005 Mar;7(2):128-32.), posted in PubMed, researchers indicated that Obesity has been demonstrated to be a major factor in the increase in CRC although links to changes in diet are more tenuous. Published studies on diet suggest the Atkins diet may help reduce rather than increase the risk of CRC.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com
B. Colon Cancer or colorectal cancer is defined as a condition of the abnormal proliferation of cells in the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Colon Cancer
1. According to the study of "Colon cancer: a civilization disorder" by Watson AJ, Collins PD. (Source from Norwich Medical School, University of East Anglia, Norwich, UK. alastair.watson@uea.ac.uk, Copyright © 2011 S. Karger AG, Basel), posted in PubMed, researchers indicated in abstract that A number of these risk factors are associated with a Western lifestyle and could be considered a product of 'civilization'. Recently, smoking has been recognized as a risk factor. Energy consumption also influences colorectal cancer risk, with obesity increasing risk and exercise reducing risk. However, the strongest contribution to environmental risk for colorectal cancer is dietary. Consumption of fat, alcohol and red meat is associated with an increased risk. Fresh fruit and vegetables and dietary fibre may be protective. Much has been learnt recently about the molecular pathogenesis of colorectal cancer.
2. In a study of "Obesity and familial obesity and risk of cancer" by Hemminki K, Li X, Sundquist J, Sundquist K. (Source from Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, Germany.k.hemminki@dkfz.de, Eur J Cancer Prev. 2011 Sep;20(5):438-43.), posted in PubMed, researchers found that Family history of obesity was associated with formerly unrecognized increased risks of gallbladder and colon cancers and ocular melanoma. Cancer risks in this relatively young obese population differed quantitatively from those found after type 2 diabetes.
3. In an abstract of the study of "Body mass index influences long-term outcome in patients with colorectal cancer" by Shibakita M, Yoshimura H, Tachibana M, Ueda S, Nagasue N. (Source from
Department of Surgery, Kawasaki Hospital, Higashiyama-cho 3-3-1, Hyogo-ku, Kobe, Hyogo 652-0042, Japan. shibakita_muneaki@kawasaki-hospital-kobe.or.jp, Hepatogastroenterology. 2010 Jan-Feb;57(97):62-9), posted in PubMed, researchers found that both high and low BMI became independent prognostic factors of disease recurrence in patients with colorectal carcinoma, as low BMI was correlated with tumor progression and high BMI influenced the number of lymph node dissected.
4. in a study of "Body size, weight change, and risk of colon cancer" by Bassett JK, Severi G, English DR, Baglietto L, Krishnan K, Hopper JL, Giles GG. (Source from Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia. julie.bassett@cancervic.org.au, Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2978-86. Epub 2010 Sep 24.), posted in PubMed, researchers found that Adult weight change was positively associated with colon cancer risk for men (HR, 1.11 per 5-kg increment; 95% CI, 1.03-1.20), but not women (HR, 1.00; 95% CI, 0.94-1.07). Men who gained ≥20 kg from age 18 had an increased risk of colon cancer compared with men whose weight was stable (HR, 1.47; 95% CI, 0.94-2.31) and concluded that
Weight gain during adult life increases men's risk of colon cancer.
5. Etc.
E. Treatments of Obesity and Colon Cancer
1. according to the abstract of the study of " Colorectal cancer screening and prevention in women" by Krishnan S, Wolf JL. (Source from Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA, Womens Health (Lond Engl). 2011 Mar;7(2):213-26), posted in PubMed, researchers stated that new studies have shown other factors such as obesity and smoking to increase the risk of CRC in women. This article highlights issues unique to women with regards to CRC and outlines special considerations for determining screening intervals in women, identifies factors that make screening more difficult in women, and reviews studies that identify preventative strategies which, together with screening, may reduce the burden of CRC.
2. According to the study of "Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis" by Pendyala S, Neff LM, Suárez-Fariñas M, Holt PR. (Source from Clinical and Translational Science Center, The Rockefeller University, New York, NY 10065, USA., Am J Clin Nutr. 2011 Feb;93(2):234-42. Epub 2010 Dec 8.), posted in PubMed, researchers found that Our data show that diet-induced weight loss in obese individuals reduces colorectal inflammation and greatly modulates inflammatory and cancer-related gene pathways. These data imply that obesity is accompanied by inflammation in the colorectal mucosa and that diet-induced weight loss reduces this inflammatory state and may thereby lower CRC risk.
3. According to the study of "Diet and colorectal cancer: implications for the obese and devotees of the Atkins diet" by Fleming ME, Sales KM, Winslet MC. (Source from University Department of Surgery, Royal Free and University College Medical School, Royal Free Hospital, London, UK, Colorectal Dis. 2005 Mar;7(2):128-32.), posted in PubMed, researchers indicated that Obesity has been demonstrated to be a major factor in the increase in CRC although links to changes in diet are more tenuous. Published studies on diet suggest the Atkins diet may help reduce rather than increase the risk of CRC.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com
Obesity and Breast Cancer
A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Breast Cancer
1. In a study of "Hormonal mechanisms underlying the relationship between obesity and breast cancer" by Perks CM, Holly JM. (Source from School of Clinical Sciences, University of Bristol, Research & Learning Building, Southmead Hospital, Bristol BS10 5NB, UK.,Copyright © 2011 Elsevier Inc. All rights reserved), posted in PubMed, researchers indicated in abstract that This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
2. According to the study of "Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study" by Jernström H, Barrett-Connor E. (Source from Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, USA., J Womens Health Gend Based Med. 1999 Dec;8(10):1265-72.), researchers indicated in abstract that The risk of breast cancer was significantly increased in women who had gained weight or used ERT. This increased risk was not associated with circulating levels of IGF-1, fasting insulin, proinsulin, or C-peptide.
3. According to" Breast cancer risk in the WHI study: the problem of obesity" by Kuhl H. (Source from Department of Gynecology and Obstetrics, J. W. Goethe University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. h.kuhl@em.uni-frankfurt.de, Maturitas. 2005 May 16;51(1):83-97.), posted in PubMed, researchers stated in abstract that Obese women are at high risk to develop a metabolic syndrome including insulin resistance and hyperinsulinemia. In postmenopausal women, elevated insulin levels are not only associated with an increased risk for cardiovascular disease, but also for breast cancer. This might explain the effects observed in both arms of the WHI study: HRT with relative low doses of estrogens may improve insulin resistance and, hence, reduce the elevated breast cancer risk in obese patients.
4. According to tha study of "Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis" by Liu C, Liu L.(Source from Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, 318000, China, liuchibo@126.com., Tumour Biol. 2011 Sep 2. [Epub ahead of print]), posted in PubMed, researchers concluded that . The present meta-analysis suggested that LEPR Q223R polymorphism might be implicated in the development of breast cancer in East Asians; PON1 L55M might increase breast cancer risk. However, given the limited sample size, the findings warrant further investigation.
5. In the study of "Obesity and breast cancer: progress to understanding the relationship" by Brown KA, Simpson ER. (Source from Prince Henry's Institute, Monash Medical Centre, Department of Physiology, Monash University, Clayton, Melbourne, Victoria, Australia, Cancer Res. 2010 Jan 1;70(1):4-7. Epub 2009 Dec 22.), posted in PubMed, researchers found that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
6. Etc.
E. Treatments of Obesity and Breast Cancer
1. According to the study of "Pre-operative gynecologic evaluation of bariatric surgery patients: improving cancer detection in a high-risk population" by Winfree LE, Henretta MS, Hallowell PT, Modesitt SC. (Source from Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.,J Am Coll Surg. 2010 Aug;211(2):256-62., Copyright 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved), posted in PubMed, researchers found that Given the massive increases in morbid obesity and bariatric surgery in women, surgeons could serve a vital role in educating patients about both gynecologic and nongynecologic malignancy risks. With appropriate referral for cancer screening, patient outcomes could improve.
2. In a study of " Alcohol consumption, obesity, estrogen treatment and breast cancer" by Hong J, Holcomb VB, Dang F, Porampornpilas K, Núñez NP. (Source from The University of Texas at Austin, College of Natural Sciences, School of Human Ecology, Department of Nutritional Science, 1 University Station A2703, PAI 5.14, Austin, Texas 78712, USA., Anticancer Res. 2010 Jan;30(1):1-8), posted in PubMed, researchers found that Alcohol intake resulted in insulin sensitivity and increased tumor growth in obese mice. Exogenous estrogen alone inhibited tumor growth. The combination of estrogen and alcohol overcame the inhibitory effects of estrogen on tumor growth in obese mice. Alcohol consumption increased the circulating estrogen and leptin levels. In conclusion, alcohol and estrogen treatment can modify mammary tumor growth, possibly through the regulation of estrogen and leptin, especially in obese mice.
3. According to the "Impact of obesity on diagnosis and treatment of breast cancer" by Deglise C, Bouchardy C, Burri M, Usel M, Neyroud-Caspar I, Vlastos G, Chappuis PO, Ceschi M, Ess S, Castiglione M, Rapiti E, Verkooijen HM. (Source from Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland, Breast Cancer Res Treat. 2010 Feb;120(1):185-93. Epub 2009 Jul 14), researchers found that Obese women were less likely to have undergone ultrasound (OR(adj) 0.5, [0.3-0.9]) and MRI (OR(adj) 0.3, [0.1-0.6]) and were at increased risk of prolonged hospital stay (OR(adj) 4.7, [2.0-10.9]). This study finds important diagnostic and therapeutic differences between obese and lean women, which may impair survival of obese women with breast cancer. Specific strategies are needed to optimize the care of obese women with or at risk of breast cancer.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
B. Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Breast Cancer
1. In a study of "Hormonal mechanisms underlying the relationship between obesity and breast cancer" by Perks CM, Holly JM. (Source from School of Clinical Sciences, University of Bristol, Research & Learning Building, Southmead Hospital, Bristol BS10 5NB, UK.,Copyright © 2011 Elsevier Inc. All rights reserved), posted in PubMed, researchers indicated in abstract that This review focuses on the influence of obesity on breast cancer development and progression and describes the hormonal factors that may underlie the observations, with particular emphasis on the roles of estrogen, insulin/insulin-like growth factor axis, and adipokines.
2. According to the study of "Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study" by Jernström H, Barrett-Connor E. (Source from Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, USA., J Womens Health Gend Based Med. 1999 Dec;8(10):1265-72.), researchers indicated in abstract that The risk of breast cancer was significantly increased in women who had gained weight or used ERT. This increased risk was not associated with circulating levels of IGF-1, fasting insulin, proinsulin, or C-peptide.
3. According to" Breast cancer risk in the WHI study: the problem of obesity" by Kuhl H. (Source from Department of Gynecology and Obstetrics, J. W. Goethe University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. h.kuhl@em.uni-frankfurt.de, Maturitas. 2005 May 16;51(1):83-97.), posted in PubMed, researchers stated in abstract that Obese women are at high risk to develop a metabolic syndrome including insulin resistance and hyperinsulinemia. In postmenopausal women, elevated insulin levels are not only associated with an increased risk for cardiovascular disease, but also for breast cancer. This might explain the effects observed in both arms of the WHI study: HRT with relative low doses of estrogens may improve insulin resistance and, hence, reduce the elevated breast cancer risk in obese patients.
4. According to tha study of "Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis" by Liu C, Liu L.(Source from Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, 318000, China, liuchibo@126.com., Tumour Biol. 2011 Sep 2. [Epub ahead of print]), posted in PubMed, researchers concluded that . The present meta-analysis suggested that LEPR Q223R polymorphism might be implicated in the development of breast cancer in East Asians; PON1 L55M might increase breast cancer risk. However, given the limited sample size, the findings warrant further investigation.
5. In the study of "Obesity and breast cancer: progress to understanding the relationship" by Brown KA, Simpson ER. (Source from Prince Henry's Institute, Monash Medical Centre, Department of Physiology, Monash University, Clayton, Melbourne, Victoria, Australia, Cancer Res. 2010 Jan 1;70(1):4-7. Epub 2009 Dec 22.), posted in PubMed, researchers found that the regulation of aromatase expression in the breast by AMPK and CRTC2, in response to the altered adipokine milieu associated with obesity, provides an important link between obesity and breast cancer risk.
6. Etc.
E. Treatments of Obesity and Breast Cancer
1. According to the study of "Pre-operative gynecologic evaluation of bariatric surgery patients: improving cancer detection in a high-risk population" by Winfree LE, Henretta MS, Hallowell PT, Modesitt SC. (Source from Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.,J Am Coll Surg. 2010 Aug;211(2):256-62., Copyright 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved), posted in PubMed, researchers found that Given the massive increases in morbid obesity and bariatric surgery in women, surgeons could serve a vital role in educating patients about both gynecologic and nongynecologic malignancy risks. With appropriate referral for cancer screening, patient outcomes could improve.
2. In a study of " Alcohol consumption, obesity, estrogen treatment and breast cancer" by Hong J, Holcomb VB, Dang F, Porampornpilas K, Núñez NP. (Source from The University of Texas at Austin, College of Natural Sciences, School of Human Ecology, Department of Nutritional Science, 1 University Station A2703, PAI 5.14, Austin, Texas 78712, USA., Anticancer Res. 2010 Jan;30(1):1-8), posted in PubMed, researchers found that Alcohol intake resulted in insulin sensitivity and increased tumor growth in obese mice. Exogenous estrogen alone inhibited tumor growth. The combination of estrogen and alcohol overcame the inhibitory effects of estrogen on tumor growth in obese mice. Alcohol consumption increased the circulating estrogen and leptin levels. In conclusion, alcohol and estrogen treatment can modify mammary tumor growth, possibly through the regulation of estrogen and leptin, especially in obese mice.
3. According to the "Impact of obesity on diagnosis and treatment of breast cancer" by Deglise C, Bouchardy C, Burri M, Usel M, Neyroud-Caspar I, Vlastos G, Chappuis PO, Ceschi M, Ess S, Castiglione M, Rapiti E, Verkooijen HM. (Source from Geneva Cancer Registry, Institute of Social and Preventive Medicine, Geneva University, 55 Boulevard de la Cluse, 1205, Geneva, Switzerland, Breast Cancer Res Treat. 2010 Feb;120(1):185-93. Epub 2009 Jul 14), researchers found that Obese women were less likely to have undergone ultrasound (OR(adj) 0.5, [0.3-0.9]) and MRI (OR(adj) 0.3, [0.1-0.6]) and were at increased risk of prolonged hospital stay (OR(adj) 4.7, [2.0-10.9]). This study finds important diagnostic and therapeutic differences between obese and lean women, which may impair survival of obese women with breast cancer. Specific strategies are needed to optimize the care of obese women with or at risk of breast cancer.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
Obesity and Skin Diseases
A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.
B. Skin infection is defined as a condition of infection of skin caused by certain bacteria, including Impetigo (a highly contagious bacterial skin infection), Erysipelas (an acute streptococcus bacterial infection), Cellulitis (a diffuse inflammation, etc. ,fungal skin infections of the skin, hair, and/or nails, parasitic infestations and viral related infections
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Skin Diseases
1. According to the study of "Skin manifestations of obesity: a comparative study" by Boza JC, Trindade EN, Peruzzo J, Sachett L, Rech L, Cestari TF. (Source from Department of Dermatology, Federal University of Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil, © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology), posted in PubMed, researchers concluded that Obesity is strongly related to several skin alterations that could be considered as markers of excessive weight. Skin care of obese patients deserves particular attention, not only because of the high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient's quality of life.
2. In the abstract of the study of " The impact of obesity on skin disease and epidermal permeability barrier status" by Guida B, Nino M, Perrino NR, Laccetti R, Trio R, Labella S, Balato N. (Source from Department of Neuroscience, Physiology Nutrition Unit, University Federico II, Naples, Italy. bguida@unina.it, J Eur Acad Dermatol Venereol. 2010 Feb;24(2):191-5. Epub 2009 Nov 19), posted in PubMed. researchers found that Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity.
3. In a study of "The influence of body mass index on skin susceptibility to sodium lauryl sulphate" by Löffler H, Aramaki JU, Effendy I. (Source from Department of Dermatology, University of Marburg, Germany. Harald.Loeffler@mailer.uni-marburg.de, Skin Res Technol. 2002 Feb;8(1):19-22.), posted in PubMed, researchers indicated that Basal biophysical parameters of the skin are primarily correlated with the BMI. This may be caused by obesity-induced physiological changes, e.g. increased sweat gland activity, high blood pressure and physiological temperature-regulating system. The epidermal barrier function, as evaluated after SLS patch testing is, however, not correlated with a high BMI, indicating a normal skin barrier.
4. In a study of "An overview of dermatological conditions commonly associated with the obese patient" by Hahler B. (Source from St. Vincent Mercy Medical Center, 2213 Cherry Street, Toledo, OH 43608, USA. hahlb@buckeye-access.com, Ostomy Wound Manage. 2006 Jun;52(6):34-6, 38, 40 passim), posted in PubMed, researchers found that with the continuing increase in the incidence of obesity, investigation into the specific care needs of this population is needed. In clinical practice, measures to reduce friction and shear and improve devices to move the obese patient would enhance care provision. Studies of the incidence of dermatological problems and the best treatments for these conditions are warranted.
5. Etc.
E. Treatments of Obesity and Skin Diseases
1. In a study of "[Skin manifestations, treatment and rehabilitation in overweight and obesity].
3. In an abstract of the studt of "Obesity and the skin: skin physiology and skin manifestations of obesity" by Yosipovitch G, DeVore A, Dawn A. (Source from Departments of Dermatology, Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. gyosipov@wfubmc.edu, J Am Acad Dermatol. 2007 Jun;56(6):901-16; quiz 917-20.) posyed in PubMed, researchers indicated that evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology. LEARNING OBJECTIVE: After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.
4. Etc.
7 Steps to Reverse Diabetes
The Most Proven And Popular Step-By-Step System
For Curing Type 1 (1st Medically Documented Case) and Type 2 Diabetes
Chinese Secrets to Fatty Liver and Obesity Reversal
A groundbreaking e book about why almost
nobody in China suffers from fatty liver or obesity
For other health articles, please visit http://medicaladvisorjournals.blogspot.com/
If you like what you read, please follow me at http://twitter.com/kylejnorton
B. Skin infection is defined as a condition of infection of skin caused by certain bacteria, including Impetigo (a highly contagious bacterial skin infection), Erysipelas (an acute streptococcus bacterial infection), Cellulitis (a diffuse inflammation, etc. ,fungal skin infections of the skin, hair, and/or nails, parasitic infestations and viral related infections
C. How do calculate your BMI index
BMI= weight (kg)/ height (m2)
D. How Obesity associates with Skin Diseases
1. According to the study of "Skin manifestations of obesity: a comparative study" by Boza JC, Trindade EN, Peruzzo J, Sachett L, Rech L, Cestari TF. (Source from Department of Dermatology, Federal University of Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil, © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology), posted in PubMed, researchers concluded that Obesity is strongly related to several skin alterations that could be considered as markers of excessive weight. Skin care of obese patients deserves particular attention, not only because of the high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient's quality of life.
2. In the abstract of the study of " The impact of obesity on skin disease and epidermal permeability barrier status" by Guida B, Nino M, Perrino NR, Laccetti R, Trio R, Labella S, Balato N. (Source from Department of Neuroscience, Physiology Nutrition Unit, University Federico II, Naples, Italy. bguida@unina.it, J Eur Acad Dermatol Venereol. 2010 Feb;24(2):191-5. Epub 2009 Nov 19), posted in PubMed. researchers found that Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity.
3. In a study of "The influence of body mass index on skin susceptibility to sodium lauryl sulphate" by Löffler H, Aramaki JU, Effendy I. (Source from Department of Dermatology, University of Marburg, Germany. Harald.Loeffler@mailer.uni-marburg.de, Skin Res Technol. 2002 Feb;8(1):19-22.), posted in PubMed, researchers indicated that Basal biophysical parameters of the skin are primarily correlated with the BMI. This may be caused by obesity-induced physiological changes, e.g. increased sweat gland activity, high blood pressure and physiological temperature-regulating system. The epidermal barrier function, as evaluated after SLS patch testing is, however, not correlated with a high BMI, indicating a normal skin barrier.
4. In a study of "An overview of dermatological conditions commonly associated with the obese patient" by Hahler B. (Source from St. Vincent Mercy Medical Center, 2213 Cherry Street, Toledo, OH 43608, USA. hahlb@buckeye-access.com, Ostomy Wound Manage. 2006 Jun;52(6):34-6, 38, 40 passim), posted in PubMed, researchers found that with the continuing increase in the incidence of obesity, investigation into the specific care needs of this population is needed. In clinical practice, measures to reduce friction and shear and improve devices to move the obese patient would enhance care provision. Studies of the incidence of dermatological problems and the best treatments for these conditions are warranted.
5. Etc.
E. Treatments of Obesity and Skin Diseases
1. In a study of "[Skin manifestations, treatment and rehabilitation in overweight and obesity].
[Article in Hungarian] by Wenczl E. (Source from Fovárosi Onkormányzat Egyesített Szent István és Szent László Kórház és Rendelointézet Borgyógyászati és Lymphológiai Rehabilitációs Osztály Budapest Nagyvárad tér 1. 1095, Orv Hetil. 2009 Sep 13;150(37):1731-8), researchers found that Draw patients' attention to the preventive importance of skin care. In case of an obese patient the usual dosage of most local and systemic drugs should be modified. It must be kept in mind that obesity directly or indirectly starts unfavorable processes in almost all organ systems. Therefore, only a multidisciplinary care may secure treatment and rehabilitation of obese patients. Dermatological and lymphological care is often part of the rehabilitation.
2. According to the study of "Dermatological complications of obesity" by García Hidalgo L. (Source from Department of Dermatology, Salvador Zubiran National Nutrition Institute, Mexico City, Mexico. lindagh@avantel.net, Am J Clin Dermatol. 2002;3(7):497-506.), posted in PubMed, researchers found that Excess load on the feet can result in morphological changes that require careful diagnosis; insoles may offer some symptom relief while control of obesity is achieved. Obesity-related dermatoses associated with hospitalization, such as pressure ulcers, diminished wound healing, dermatoses secondary to respiratory conditions, and incontinence, must all be carefully managed with an emphasis on prevention where possible. Recognition and control of the dermatological complications of obesity play an important role in diminishing the morbidity of obesity.3. In an abstract of the studt of "Obesity and the skin: skin physiology and skin manifestations of obesity" by Yosipovitch G, DeVore A, Dawn A. (Source from Departments of Dermatology, Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. gyosipov@wfubmc.edu, J Am Acad Dermatol. 2007 Jun;56(6):901-16; quiz 917-20.) posyed in PubMed, researchers indicated that evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology. LEARNING OBJECTIVE: After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology, skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.
4. Etc.
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